Research progress of gut microbiota and primary biliary cholangitis / 医学研究生学报

ABSTRACT

Primary biliary Cholangitis (PBC) is a cholestatic autoimmune liver disease with a prolonged course and poor prognosis. The intestinal micro-ecological system is composed primarily by intestinal mucosa and gut microbiota. The system is closely related to the liver in function and anatomy, mediates the gut-liver axis and participates in maintaining various physiological, immune and metabolic functions of the body. Analysis of the relationship between the gut microbiota and PBC may provide new treatment ideas for clinical treatment of PBC. This article mainly reviews the relationship between gut microbiota imbalance and disease, the interaction of gut microbiota and its metabolites with the liver, and the potential value of fecal microbiota transplantation in the treatment of PBC.