Association between mandibular prognathism and the candidate gene GHR in the Han Chinese in Hong Kong / 医学研究生学报

ABSTRACT

Objective　Studies on the location of the susceptibility genes of mandibular prognathism are mostly conducted by association analysis. The aim of this study was to investigate the correlation between the single nucleotide polymorphism (SNP) of the candidate gene of the growth hormone receptor (GHR) and mandibular prognathism in the Han Chinese in Hong Kong. Methods We selected 7 tag SNPs (tSNP) in the GHR gene from 211 cases of mandibular prognathism and 224 controls among the Han Chinese in Hong Kong. We genotyped the tSNPs using the MassARRAY System and analyzed the association of individual SNPs and the relevant haplotypes with mandibular prognathism.　Results　The SNP rs6898743 of the GHR gene was found associated with mandibular prognathism in genotypic frequency (P = 0.036) and allelic distribution (P = 0.015), and the G allele of rs6898743 associated with a significantly decreased risk of mandibular prognathism (OR 0.72; 95% CI 0.55-0.94). Linkage disequilibrium analysis revealed the association of mandibular prognathism with the haplotypes GAA (P = 0.014) and GAG (P = 0.012).　Conclusion　The SNP locus rs6898743 of the GHR gene is associated with mandibular prognathism in the Han Chinese in Hong Kong