Research progress on the correlation between TLR4 signalling pathways and the renal interstitial fibrosis / 医学研究生学报

ABSTRACT

Renal fibrosis is considered an aberrant form of injury⁃ or stress⁃induced wound healing accompanied by excessive ECM deposition. Inflammation plays an important role in renal interstitial fibrosis. TLR4 signalling pathway Up⁃regulation can promote inflammatory factors, chemokines secretion and modualte macrophage polarization. In this paper, we review the recent advances in TLR4 signalling pathway and its role in renal fibrosis, and TLR4 signalling pathway targeted therapy in renal fibrosis so as to provide referrence for related research in the future.