Recent progress on the relationship between P2X7R and breast cancer / 医学研究生学报

ABSTRACT

As the P2X receptor family has become a research hotspot in recent years, the study on P2X7 receptor has also received extensive attention. P2X7 receptor (P2X7R) is a dual-transmembrane cation-channel receptor, which is gated in vivo by adenosine triphosphate (ATP) and can be activated. Activated P2X7 receptor can produce such effects as cationic channel opening, signal pathway activation, inflammatory mediator release and cell apoptosis. It plays an important role in the development of various tumors and inflammatory diseases. Studies have shown that the abnormal expression of P2X7 receptor affects the occurrence and development of breast cancer by activating a series of signaling pathways, which is expected to become a new target for designing anti-breast cancer drugs. Other studies have shown that multiple microRNAs can promote the occurrence and development of breast cancer by regulating the expression of P2X7 receptor gene. In this review, we reviewed the recent research advances of P2X7 receptor and the relationship between breast cancer and its abnormal expression.