Biological role of hypoxic microenvironment in pancreatic cancer / 临床肝胆病杂志

ABSTRACT

Hypoxia caused by rapid growth of cancer cells and insufficient central blood supply is one of the characteristics of tumor microenvironment, especially in pancreatic cancer. An increasing number of studies have shown that hypoxia is closely associated with angiogenesis, metabolic reprogramming, tumor proliferation, and early invasion and metastasis of pancreatic cancer and can mediate tumor immune evasion by secreting a variety of active factors. In addition, as a key factor for the low cure rate of pancreatic cancer, drug resistance is also associated with hypoxia. Hypoxia is closely associated with the development and progression of pancreatic cancer and depends on hypoxia-inducible factor. This article summarizes the association between hypoxic microenvironment and pancreatic cancer and discusses the activation of related signaling pathways and molecular mechanisms, in order to provide clues for targeted therapy for hopoxic microenvironment in pancreatic cancer.