Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol-induced urolithiasis model of rats
Asian Pacific Journal of Tropical Medicine
;
(12): 533-538, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-819637
ABSTRACT
OBJECTIVE@#To investigate the antilithiatic effect of the whole Leea macrophylla (L. macrophylla) Roxb (Leeaceae) ethanol extract in ethylene glycol-induced urolithiasis model of rats.@*METHODS@#Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely preventive (n=18) and therapeutic (n=24). Preventive group was further subdivided into 3 groups of 6 rats namely preventive control (PC), preventive lithiatic control (PLC) and preventive lithiatic L. macrophylla (PLLM). Similarly, therapeutic group was also subdivided into 4 groups of 6 rats namely therapeutic control (TC), therapeutic lithiatic control (TLC), therapeutic lithitatic L. macrophylla (TLLM) and therapeutic lithiatic cystone (TLCYS). The lithiasis was induced by 0.75% (v/v) ethylene glycol in the drinking water of all groups except the PC and TC groups. The urinary ionic parameters such as calcium, inorganic phosphate, oxalate, magnesium & creatinine and renal morphology were altered by ethylene glycol, which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L. macrophylla extract (500 mg/kg BW daily).@*RESULTS@#Significant difference on recovery was observed between preventive and therapeutic interventional trials. Anti-urolithiatic effect of cystone was significantly (P<0.001) higher than extracts. L. macrophylla extract was found nontoxic in the acute toxicity test.@*CONCLUSION@#The results of this study demonstrated very promising anti-urolithiatic effect of L. macrophylla extract with preventive and therapeutic treatments in this experimental condition.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamaño de los Órganos
/
Patología
/
Farmacología
/
Orina
/
Cicatrización de Heridas
/
Oxalato de Calcio
/
Fosfatos de Calcio
/
Extractos Vegetales
/
Cálculos Renales
/
Distribución Aleatoria
Límite:
Animales
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2012
Tipo del documento:
Artículo
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