Hepatic effect of NAC on sevear acute pancteatise of rats

ABSTRACT

OBJECTIVE@#To analyze the hepatic protection of n-acetyl cysteine (NAC) on severe acute pancreatitis (SAP).@*METHODS@#SD rats were randomly divided into control group, SAP group and NAC group. SAP AHO method was adopted to establish the model, 2 h after modeling, rats in NAC group had intraperitoneal injection of NAC (200 mg/kg). Ten rats from each group were sacrificed in every 6 and 12 h at different time points respectively. Liver damage, liver function and serum amylase, AST, ALT and malondialdehyde (MDA) were determined.@*RESULTS@#Serum amylase, AST, ALT and MDA content in SAP, NAC group at each time point were significantly higher in the control group (P<0.05), serum amylase, AST, ALT and MDA content in NAC group rats were lower in the SAP group significantly (P<0.05); Microscopic examination showed that the liver injury in rats and the NAC group significantly reduced in the SAP group.@*CONCLUSIONS@#NAC provides effective protection against liver damage to SAP, protective from SAP liver injury.