Relationship between expression of COX-2, TNF-α, IL-6 and autoimmune-type recurrent miscarriage
Asian Pacific Journal of Tropical Medicine
;
(12): 990-994, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-819743
ABSTRACT
OBJECTIVE@#To investigate the roles of COX-2, TNF-α, IL-6 in the pathogenesis of autoimmune-type recurrent spontaneous abortion (RSA).@*METHODS@#RT-PCR was used to detect the mRNA of COX-2, TNF-α, IL-6 in the trophoblast cells of murine RSA and normal pregnant models. The COX-2, TNF-α, IL-6 protein expressions were determined by using immunohistochemisry staining method. The COX-2, TNF-α, IL-6 protein expressions were determined by ELISA.@*RESULTS@#The embryo loss rates in experiment group was significantly higher than that in normal pregnancy control group, the expression of COX-2, TNF-α, IL-6 in the trophoblast cells of murine RSA and normal pregnant models. The expression of COX-2 in autoimmune-type recurrent spontaneous abortion was significantly lesser than in normal pregnant models. The expression of TNF-α, IL-6 in autoimmune-type recurrent spontaneous abortion was significantly higher than in normal pregnant models. There was a positively correlation between TNF-α and IL-6. There was no relationship between COX-2, TNF-α and IL-6.@*CONCLUSIONS@#The abnormal expression of COX-2, TNF-α and IL-6 may result in RSA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trofoblastos
/
Sangre
/
Autoinmunidad
/
Química
/
Aborto Habitual
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Estadísticas no Paramétricas
/
Relaciones Materno-Fetales
/
Modelos Animales de Enfermedad
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2013
Tipo del documento:
Artículo
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