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Influence of Withania somnifera on obsessive compulsive disorder in mice
Asian Pacific Journal of Tropical Medicine ; (12): 380-384, 2012.
Artículo en Inglés | WPRIM | ID: wpr-819763
ABSTRACT
OBJECTIVE@#To study the influence of methanolic and aqueous extract of Withania somnifera (W. somnifera) root on the marble-burying behavior of mice a well-accepted model of obsessive compulsive behavior.@*METHODS@#Mice were divided in different groups (n = 6). Fluoxetine (5, 10, 15 mg/kg), (10, 25, 50, 100 mg/kg) and methanolic extract W. somnifera (MEWS) (10, 25, 50, 100 mg/kg) were administered i.p. 30 min. prior to the assessment of marble burying behavior and locomotor activity. The control group received vehicle of the extract.@*RESULTS@#Administration of aqueous extracts W. somnifera (AEWS) and MEWS (50 mg/kg) successively decreased the marble burying behavior activity without affecting motor activity. This effect of AEWS and MEWS was comparable to standard fluoxetine, ritanserin and parachlorophenylalanine.@*CONCLUSIONS@#W. somnifera extract is effective in treating obsessive compulsive disorder.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Ansiolíticos / Extractos Vegetales / Análisis de Varianza / Ritanserina / Raíces de Plantas / Withania / Quimioterapia / Fitoterapia / Métodos Límite: Animales Idioma: Inglés Revista: Asian Pacific Journal of Tropical Medicine Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Ansiolíticos / Extractos Vegetales / Análisis de Varianza / Ritanserina / Raíces de Plantas / Withania / Quimioterapia / Fitoterapia / Métodos Límite: Animales Idioma: Inglés Revista: Asian Pacific Journal of Tropical Medicine Año: 2012 Tipo del documento: Artículo