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Expression and significance of p53 and mdm2 in patients with leukoplakia cancer
Asian Pacific Journal of Tropical Medicine ; (12): 831-834, 2013.
Artículo en Inglés | WPRIM | ID: wpr-819961
ABSTRACT
OBJECTIVE@#To study the relationship of the expressions of p53 and mdm2 in leukoplakia cancer.@*METHODS@#RT-PCR was used to detect the mRNA of p53, mdm2 in patients with leukoplakia cancer. The frequencies of p53, mdm2 in peripheral blood were detected by flow cytometric analysis.@*RESULTS@#The expression of p53mRNA in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were 7.7%, 27.3%,33.3%, 56.8%, respectively. The frequencies of p53 in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were (0.3±0.1)%, (1.6±0.9)%, (1.9±1.1)%, (3.4±1.8)%. The expression of mdm2 mRNA in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were 0.0%, 6.8%, 11.1%, 37.8%, respectively. The frequencies of mdm2 in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were (0.1±0.1)%, (0.8±0.6)%, (1.2±0.8)%, (1.2±0.8)%. There was a positively correlation between p53 mRNA and mdm2 mRNA.@*CONCLUSIONS@#The positive rate of p53 and mdm2 cells in the peripheral blood increases in patients with leukoplakia cancer tissue and has positive correlation with the severity of leukoplakia cancer.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Regulación Neoplásica de la Expresión Génica / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas c-mdm2 / Genética / Leucoplasia / Metabolismo Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Inglés Revista: Asian Pacific Journal of Tropical Medicine Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Regulación Neoplásica de la Expresión Génica / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas c-mdm2 / Genética / Leucoplasia / Metabolismo Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Inglés Revista: Asian Pacific Journal of Tropical Medicine Año: 2013 Tipo del documento: Artículo