Inhibitory effect of the paraoxonase gene on the formation of rabbit coronary atherosclerosis

ABSTRACT

OBJECTIVE@#To observe the effect on the inhibition of coronary atherosclerosis hardening of the paraoxonase gene (PON-1) which transfected to the rabbit epicardial adipose tissue.@*METHODS@#Rabbit coronary atherosclerosis model was established by high-fat feeding, liposome-encapsulated recombinant plasmid pEGFP-PON-1 50 μ L was injected to the rabbit pericardial cavity, and was harvested 4 weeks after transfection.@*RESULTS@#The epicardial fat transfected PON-1 gene had effect on the high lipid level. It significantly increased expression of PON-1 in peripheral arterial vascular tissue (P <0.05); and significantly reduced total cholesterol and low-density lipoprotein cholesterol levels (P<0.05), and the thickness ratio of coronary artery intima/media (P <0.05).@*CONCLUSIONS@#The injection of the PON-1 gene in the pericardial cavity can effectively suppress the formation of coronary atherosclerosis.