Effect of atorvastatin on expression of TLR4 and NF-κB p65 in atherosclerotic rabbits
Asian Pacific Journal of Tropical Medicine
;
(12): 493-496, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-820014
ABSTRACT
OBJECTIVE@#To study the effect of atorvastatin on atherosclerotic rabbits.@*METHODS@#A total of 60 New Zealand male rabbits were randomly divided into the normal group, model group and atorvastatin group. The replication rabbit atherosclerotic model with immune injury combined with a high fat diet feeding was used. All rabbits were sacrificed after 3 months. TLR4 and NF-κB p65 were observed by HE staining, immunohistochemistry and western blotting.@*RESULTS@#The expression of TLR4, NF-κB p65 were significantly increased in the model group compared with the normal group. The expression of TLR4 and NF-κB p65 decreased significantly in the atorvastatin group, and there was no difference compared with the normal group.@*CONCLUSIONS@#The effect of atorvastatin on atherosclerosis may be achieved by the inhibition of the expression of TLR4 and NF-κB p65.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aorta
/
Farmacología
/
Pirroles
/
Sangre
/
Distribución Aleatoria
/
Expresión Génica
/
Modelos Animales de Enfermedad
/
Quimioterapia
/
Aterosclerosis
/
Factor de Transcripción ReIA
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2013
Tipo del documento:
Artículo
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