Expression of NF-κB and osteopontin of synovial fluid of patients with knee osteoarthritis
Asian Pacific Journal of Tropical Medicine
;
(12): 379-382, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-820513
ABSTRACT
OBJECTIVE@#To explore the significance of osteopontin and nuclear factor κB (NF-κB) expression in patients with knee osteoarthritis.@*METHODS@#RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin (OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures, and analyze the relationship between the expressiones of them.@*RESULTS@#OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group. the result showed statistical significance (P<0.05). There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P<0.05).@*CONCLUSIONS@#The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Líquido Sinovial
/
ARN Mensajero
/
Estudios de Casos y Controles
/
Western Blotting
/
Reacción en Cadena de la Polimerasa
/
FN-kappa B
/
Estadísticas no Paramétricas
/
Osteoartritis de la Rodilla
/
Osteopontina
/
Genética
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2013
Tipo del documento:
Artículo
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