Wound healing effect of flavonoid rich fraction and luteolin isolated from Martynia annua Linn. on streptozotocin induced diabetic rats
Asian Pacific Journal of Tropical Medicine
; (12): 253-259, 2013.
Article
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ABSTRACT
OBJECTIVE@#To evaluate wound healing potential of flavonoid fractions of Martynia annua (M. annua) Linn. leaves in diabetic rats on the basis of folkloric information and preliminary study.@*METHODS@#The flavonoid compound luteolin and apigenin were isolated from dried leaves of plant by column chromatography. The two concentrations (0.2% and 0.5% w/w) of luteolin and flavonoid fraction were selected for topically applied as ointment on diabetic wound. The Povidone Iodine Ointment USP was used as a reference. On 18th days, protein content, hydroxyproline and antioxidants (SOD, CAT and GSH) level in granuloma tissues were determined.@*RESULTS@#The results showed that, percent wound contraction were observed significantly (P<0.01) greater in MAF fraction and 0.5% w/w of luteolin treatment groups. Presence of matured collagen fibres and fibroblasts with better angiogenesis were observed in histopathological studies.@*CONCLUSIONS@#In conclusion, our findings suggest that flavonoid fraction (MAF) and luteolin (0.5% w/w) may have potential benefit in enhancing wound healing in diabetic condition, possibly due to free-radical scavenging activity of plant.
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Asunto principal:
Pomadas
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Patología
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Farmacología
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Piel
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Cicatrización de Heridas
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Flavonoides
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Administración Cutánea
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Extractos Vegetales
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Proteínas
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Química
Límite:
Animals
Idioma:
En
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2013
Tipo del documento:
Article