Rabbit model of radiation-induced lung injury
Asian Pacific Journal of Tropical Medicine
;
(12): 237-241, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-820534
ABSTRACT
OBJECTIVE@#To explore the feasibility of establishing an animal model of chronic radiation-induced lung injury.@*METHODS@#Twenty-eight New Zealand white rabbits were randomly divided into 3 groups (the right lung irradiation group, the whole lung irradiation group and the control group). Animal model of radiation-induced lung injury was established by high-does radiotherapy in the irradiation groups, then all rabbits underwent CT and pathological examinations at 1, 2, 4, 8, 12, 16 weeks, respectively after radiation.@*RESULTS@#Within 4 weeks of irradiation, some rabbits in the right lung irradiation group and whole lung irradiation group died. CT and pathological examinations all showed acute radiation pneumonitis. At 8-12 weeks after irradiation, CT scanning showed ground glass samples signs, patchy shadows and fibrotic stripes. Pathological examination showed the fibrosis pulmonary alveolar wall thickened obviously.@*CONCLUSIONS@#The clinical animal model of chronic radiation-induced lung injury which corresponds to practical conditions in clinic can be successfully established.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Alveolos Pulmonares
/
Traumatismos Experimentales por Radiación
/
Factores de Tiempo
/
Diagnóstico por Imagen
/
Tomografía Computarizada por Rayos X
/
Estudios de Factibilidad
/
Neumonitis por Radiación
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2013
Tipo del documento:
Artículo
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