Expression and significance of VEGF and p53 in degenerate intervertebral disc tissue
Asian Pacific Journal of Tropical Medicine
;
(12): 79-81, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-820562
ABSTRACT
OBJECTIVE@#To investigate the mechanism of expression and significance of vascular endothelial growth factor (VEGF) and p53 in degenerate intervertebral disc tissue.@*METHODS@#Pathological sections collected from 156 patients with lumbar disc herniation after surgery were tested by immunohistochemistry method, for evaluation of the expression of VEGF and p53 in degenerate intervertebral disc tissue.@*RESULTS@#98 cases (62.8%) with vascular infiltration phenomenon are found, and positive rates of VEGF and p53 in degenerate intervertebral disc tissue are 73.42% (116/156) and 58.97% (92/156); co-expression rate is 53.2%(83/156); the expression rates of VEFG and p53 are significantly higher in the tissue with blood vessel infiltration than in the tissue without infiltration; there is a close relationship of VEGF with p53.@*CONCLUSIONS@#VEGF and p53 gene synergetic express in degenerate intervertebral disc tissue, working together in neovascularization and infiltration, and accelerating intervertebral disc tissue degeneration.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Inmunohistoquímica
/
Estudios de Casos y Controles
/
Distribución de Chi-Cuadrado
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Proteína p53 Supresora de Tumor
/
Factor A de Crecimiento Endotelial Vascular
/
Degeneración del Disco Intervertebral
/
Disco Intervertebral
/
Metabolismo
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2013
Tipo del documento:
Artículo
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