TIRAP rs8177374 gene polymorphism increased the risk of pulmonary tuberculosis in Zahedan, southeast Iran
Asian Pacific Journal of Tropical Medicine
;
(12): 451-455, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-820672
ABSTRACT
OBJECTIVE@#To evaluate the possible association between Toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP; also known as MAL) rs1893352 and rs8177374 (S180L) gene polymorphisms and pulmonary tuberculosis (PTB) in a sample of Iranian population.@*METHODS@#This case-control study was performed on 174 PTB and 177 healthy subjects. Tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) was used to detect the polymorphisms.@*RESULTS@#Our finding showed that neither the overall Chi-square comparison of PTB and control subjects nor the logistic regression analysis indicated any association between rs1893352 polymorphism and PTB. Regarding rs8177374 polymorphism, the CT genotype as well as CT+TT increased the risk of PTB in comparison with CC genotype (OR=4.73, 95% CI=2.65-8.45, P<0.0001 and OR=6.47, 95% CI=3.68-11.38, P<0.0001, respectively). The rs8177374 T allele increased the risk of PTB in comparison with C allele (OR=4.21, 95% CI=2.43-7.26, P<0.0001).@*CONCLUSIONS@#Our finding indicates that TIRAP rs8177374 polymorphism is associated with PTB in a sample of Iranian population.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tuberculosis Pulmonar
/
Glicoproteínas de Membrana
/
Estudios de Casos y Controles
/
Epidemiología
/
Receptores de Interleucina-1
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Genética
/
Irán
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2014
Tipo del documento:
Artículo
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