Association between cytochrome P450 gene polymorphism and drug-induced liver injury / 临床肝胆病杂志
Journal of Clinical Hepatology
; (12): 1150-1153, 2020.
Article
en Zh
| WPRIM
| ID: wpr-822005
Biblioteca responsable:
WPRO
ABSTRACT
As the prevalence rate of drug-induced liver injury increases year by year, the pathogenesis of drug-induced liver injury has become the focus of attention. As a large family, CYP450 enzymes participate in almost all oxidative metabolic reactions of drugs in the human liver. Recent studies have shown that CYP450 enzyme gene polymorphisms lead to the differences in pharmacodynamics between individuals, and therefore, exploring the role of CYP450 enzyme gene polymorphisms in drug-induced liver injury may promote the understanding of the pathogenesis of drug-induced liver injury. This article reviews the CYP450 enzyme polymorphisms that have been found to be associated with drug-induced liver injury.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Clinical Hepatology
Año:
2020
Tipo del documento:
Article