Plasma asymmetric dimethylarginine and its association with some of cardiovascular disease risk factors in chronic kidney disease
The Medical Journal of Malaysia
;
: 209-214, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-822674
ABSTRACT
@#Introduction:
Chronic kidney disease (CKD) usually has increase of asymmetric dimethylarginine (ADMA) levels. ADMA is a cardiovascular disease (CVD) risk factor and its elevation associated with other CVD risk factors at CKD leads to increasing risk of death. In this article, we aimed to identify levels and elevation proportion of plasma ADMA in CKD as well as association between ADMA with CVD risk factors.Methods:
This cross-sectional study was performed at Hue Central Hospital from 2012-2016 on 176 CKD and 64 control subjects. ADMA levels were measured by using the enzyme linked immunosorbent assay (ELISA) method.Results:
Mean ADMA level was markedly higher (p<0.001) in all patients combined (0.73±0.24µmol/L) than in control subjects (0.47±0.13µmol/L). Mean ADMA levels in advanced kidney disease were higher than control subjects. ADMA levels correlated inversely and relatively strictly to estimated glomerular filtration rate (eGFR) (r = -0.689; p<0.001), haemoglobin (r = -0.525; p<0.001) and haematocrit (r = - 0.491; p<0.001); correlated favourably and relatively strictly to serum creatinine (r = 0.569; p<0.001) and serum urea (r = 0.642; p<0.001). ADMA elevation was predicted simultaneously by eGFR<60 mL/min/1.73m2 (p<0.001), anaemia (p=0.002), body mass index (BMI) (p=0.011) and high sensitivity C-reactive protein (hs-CRP) (p=0.041). Cutoff of ≥0.68µmol/L, ADMA levels predict reduction of eGFR<60 mL/min/1.73m2 , sensitivity of 86.9 %, specificity of 82.6%, area under ROC 92.4% (95%CI 88.6-96.1%).
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Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Revista:
The Medical Journal of Malaysia
Año:
2019
Tipo del documento:
Artículo
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