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Multivariate survival analysis of the patients with recurrent endometrial cancer / 부인종양
Journal of Gynecologic Oncology ; : 3-8, 2011.
Artículo en Inglés | WPRIM | ID: wpr-82288
ABSTRACT

OBJECTIVE:

Few studies on the prognosticators of the patients with recurrent endometrial cancer after relapse have been reported in the literature. The aim of this study was to determine the prognosticators after relapse in patients with recurrent endometrial cancer who underwent primary complete cytoreductive surgery and adjuvant chemotherapy.

METHODS:

Thirty-five patients with recurrent endometrial cancer were included in this retrospective analysis. The prognostic significance of several clinicopathological factors including histologic type, risk for recurrence, time to relapse after primary surgery, number of relapse sites, site of relapse, treatment modality, and complete resection of recurrent tumors were evaluated. Survival analyses were performed by Kaplan-Meier curves and the log-rank test. Independent prognostic factors were determined by multivariate Cox regression analysis.

RESULTS:

Among the clinicopathological factors analyzed, histologic type (p=0.04), time to relapse after primary surgery (p=0.03), and the number of relapse sites (p=0.03) were significantly related to survival after relapse. Multivariate analysis revealed that time to relapse after primary surgery (hazard ratio, 6.8; p=0.004) and the number of relapse sites (hazard ratio, 11.1; p=0.002) were independent prognostic factors for survival after relapse. Survival after relapse could be stratified into three groups by the combination of two independent prognostic factors.

CONCLUSION:

We conclude that time to relapse after primary surgery, and the number of relapse sites were independent prognostic factors for survival after relapse in patients with recurrent endometrial cancer.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recurrencia / Análisis de Supervivencia / Análisis Multivariante / Estudios Retrospectivos / Neoplasias Endometriales Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos Idioma: Inglés Revista: Journal of Gynecologic Oncology Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recurrencia / Análisis de Supervivencia / Análisis Multivariante / Estudios Retrospectivos / Neoplasias Endometriales Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos Idioma: Inglés Revista: Journal of Gynecologic Oncology Año: 2011 Tipo del documento: Artículo