Molecular mechanisms of hepatobiliary and pancreatic diseases in patients with inflammatory bowel disease / 临床肝胆病杂志

ABSTRACT

Inflammatory bowel disease (IBD) is a non-specific chronic intestinal inflammatory disease with unknown etiology and pathogenesis and is often accompanied by extraintestinal manifestations involving multiple organs including the liver, the gallbladder, and the pancreas, with an important impact on the prognosis of IBD. Hepatobiliary and pancreatic complications mainly include primary sclerosing cholangitis, primary biliary cholangitis, autoimmune hepatitis, IgG4-associated sclerosing cholangitis, acute pancreatitis, chronic pancreatitis, autoimmune pancreatitis, and nonspecific increase in pancreatic enzyme. IBD-related hepatobiliary and pancreatic complications are caused by the combination of environmental and immune-mediated factors in individuals with genetic susceptibility, and this article summarizes the current research advances in the pathogenesis of such hepatobiliary inflammatory bowel disease;liver diseases;biliary tract diseases;pancreatic diseases;and pancreatic complications.