Progress of astrocytes and their exosomes in central nervous system disease / 国际儿科学杂志

ABSTRACT

Astrocytes exist in the central nervous system widely,through cell-cell communication in neurovascular units,playing an important role in providing metabolic support for neurons,regulating nerve function and plasticity and so on.There is evidence that exosomes play a key regulatory role in intercellular communication by carrying natural cargo molecules and participate in a variety of pathophysiological processes.However,the role of astrocyte-derived exosome in central nervous system diseases is largely unknown.In this paper,the classification,characteristics,biomarkers,physiological functions,functions of astrocyte-derived exosome and their roles in central nervous system diseases are reviewed,for a deeper understanding of the role of astrocytes in central nervous system diseases.