Progress of Klotho protein on anti-renal interstitial fibrosis / 国际儿科学杂志

ABSTRACT

Klotho (KL) protein is a membrane-bound protein mainly expressed in the kidney and brain.It can regulate the expression of multiple signal pathways and target genes,such as ion channels,transforming growth factor (TGF),and exert anti-aging effects,kidney protection,anti-tumor and regulating metabolism.Recent studies have found that KL protein plays an important role in renal diseases such as renal interstitial fibrosis (RIF).KL deficiency can induce and promote the progress of RIF,and KL overexpression or supplementation can prevent RIF.This review focuses on the anti-RIF effect of KL protein through multiple signaling pathways,and aims to provide a new direction for anti-RIF therapy.