Effects of dietary polyunsaturated fatty acid intake on serum lipoprotein, C-reactive protein and homocysteine in patients with acute ischemic stroke or transient ischemic attack / 国际脑血管病杂志

ABSTRACT

Objective To investigate the relationship between dietary polyunsaturated fatty acid (PUFA) intake and blood lipid,C-reactive protein (CRP) and homocysteine (Hcy) in patients with acute ischemic stroke or transient ischemic attack (TIA).Methods Patients with acute ischemic stroke or TIA were enrolled consecutively from Nanjing Stroke Registry Program.The total dietary PUFA intake level was assessed by the food semi-quantitative frequency questionnaire.Venous blood samples were collected in the morning of the day after admission to the hospital to detect the levels of serum total cholesteroI,triacylglycerol,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,Hcy,and CRP.According to the median level of total PUFA intake,the patients were divided into low PUFA group and high PUFA group.The rehtionship between PUFA intake and blood lipid,CRP and Hcy was analyzed by Spearman correhtion analysis,and multiple linear regression analysis was used to determine the independent correhtion.Results A total of 170 patients (85.1％) with acute ischemic stroke and 31 patients with TIA (14.9％) were enrolled.Their age was 62.9 ± 14.1 years,143 were males (71.1％),and the median PUFA daily intake was 12.8 g (interquartile range8.05-17.5 g).Compared with the high PUFA group (n =100),patients in the low PUFA group (n =101) were older,serum high-density lipoprotein cholesterol levels were lower,and CRP and Hcy levels were higher.The above differences were statistically significant (all P ＜ 0.05).Spearman correlation analysis showed that total dietary PUFA intake was significantly negatively correhted with the serum CRP (r =-0.24,P =0.001) and Hey (r =-0.17,P =0.013) levels,and there was no significant correlation with the blood lipid levels.Multiple linear regression analysis showed that CRP was significantly negatively correlated with PUFA intake after adjusting for confounding factors (B =-0.28,P =0.012).Conclusions Dietary PUFA intake in patients with acute ischemic stroke or TIA may affect blood metabolism index and oxidative stress index.It is necessary to adjust the dietary structure of patients with low PUFA intake to reduce the risk of stroke recurrence.