Application of stereotactic body radiation therapy in advanced renal cell carcinoma / 国际肿瘤学杂志

ABSTRACT

Stereotactic body radiation therapy (SBRT)can effectively kill renal cancer cells by biologi-cal molecules such as hypoxia-inducible factor-1α and acid sphingomyelinase. SBRT regimen with higher biological dose and single irradiation can achieve more effective local control of primary and metastatic lesion of advanced renal cancer,and adverse reactions can be tolerated. Combination of SBRT and targeted drugs can increase the sensitivity of renal cancer to radiotherapy,and the combination of SBRT and immune drugs can enhance the immune response through the abscopal effect. The efficacy of SBRT in the treatment of advanced renal cancer remains to be explored.