Human telomerase reverse transcriptase and cutaneous malignant tumor / 国际肿瘤学杂志

ABSTRACT

Human telomerase reverse transcriptase (hTERT)is a catalytic subunit of telomerase and is closely related to immortalization of cells,tumorigenesis and senescence of cells. hTERT has a great relation-ship with the occurrence and development of skin malignant tumors (melanoma,squamous cell carcinoma, basal cell carcinoma,cutaneous lymphoma,etc. ). Abnormal expression of hTERT has important clinical appli-cation value in early diagnosis,individualized comprehensive treatment and prognosis evaluation of cutaneous malignant tumors.