Effect of liraglutide combined with clomiphene on serum sex hormone levels and natural conception rate in obese women with polycystic ovary syndrome / 中国基层医药

ABSTRACT

Objective To explore the effect of liraglutide combined with clomiphene on serum hormone levels and natural conception rate in obese patients with polycystic ovary syndrome .Methods A total of 89 infertile patients with obese polycystic ovary syndrome who were treated in the First People's Hospital of Jinzhong from April 2015 to March 2016 were selected.They were randomly divided into observation group (n=45) and control group (n=44) by simple randomization method .The control group was treated with clomiphene citrate , and the observation group was given liraglutide combined with clomiphene .The fasting blood glucose ( FPG ) , glycosylated hemoglobin (HbAc1),BMI,follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),total cholesterol (TC),triglyceride (TG),high-density lipoprotein(HDL-C),and low-density lipoprotein(LDL-C) before and after treatment were compared .The menstrual cycle rate ,normal ovulation ,normal conception ,early embryo death ,and incidence rate of adverse reaction were recorded after treatment .Results After treatment,the FPG,HbAc1 and BMI in the observation group were significantly lower than those in the control group ( t1 =4.144,t2 =5.862,t3 =5.403,all P<0.05).After treatment,the levels of FSH,LH and T in the observation group were lower than those in the control group(t1 =5.972,t2 =5.359,t3 =6.603,all P<0.05).The levels of TC,TG and LDL-C in the observation group were significantly lower than those in the control group (t1 =10.697,t2 =5.344,t3 =6.986,all P<0.05).The HDL-C of the observation group was higher than that of the control group (t=4.340,P<0.05).After treatment,the menstrual cycle rate,normal ovulation rate ,natural conception rate of the observation group were 91.11％,84.44％,80.00％, respectively,which were higher than those of the control group (72.72％,61.36％,54.54％) (χ21 =5.099,χ22 =6.017,χ23 =6.562,all P<0.05).The early embryo mortality rate of the observation group was 6.67％,which was lower than 27.27％ of the control group (χ2 =6.741,P<0.05).The total incidence of adverse reactions in the observation group was 8.89％,which was lower than 29.55％ in the control group (χ2 =6.143,P <0.05). Conclusion Liraglutide combined with clomiphene in the treatment of obese polycystic ovary syndrome infertility patients can effectively reduce the body weight ,regulate blood lipids ,glucose metabolism ,sex hormone levels ,improve the natural conception rate of patients ,reduce the incidence of adverse reactions .Its effect is significant .