Advances in the study of apatinib-induced hand-foot skin reaction / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 962-964, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-824326
ABSTRACT
Apatinib mesylate is a novel small molecule monoclonal antibody. Its mechanism of action is through highly selective com-petition for intracellular vascular endothelial growth factor receptor-2 (VEGFR-2) ATP binding sites and blocking downstream signal transduction thereby inhibiting neovascularization of tumor tissue. Hand-foot skin reaction (HFSR) is one of the common adverse reac-tions of apatinib, and it often affects the quality of life of patients; this leads to a reduction in the use of targeted drugs , which nega-tively affects the efficacy of anti-tumor therapy. The conventional western medicine treatment for HFSR comprises urea and glucocorti-coid topical preparations. Clinical treatment is often based on redness, ulceration, scab, and other skin manifestations; a combination of Chinese and western medicines can improve clinical outcomes. This article reviews apatinib-related HFSR and the relevant progress in treatment strategies in order to provide a clinical reference.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Clinical Oncology
Año:
2019
Tipo del documento:
Artículo
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