Effect of ABCB1 C3435T genetic polymorphism on efficacy of postoperative analgesia / 中华麻醉学杂志

ABSTRACT

Objective To evaluate the effect of ATP-binding cassette B subfamily member 1 transporter (ABCB1) C3435T genetic polymorphism on the efficacy of postoperative analgesia.Methods One hundred American Society of Anesthesiologists physical status Ⅱ or Ⅲ patients,aged 18-60 yr,scheduled for elective thoracoscopic lobectomy under general anesthesia,were enrolled in this study.The gene mutation of ABCB1 C3435T was detected,and the patients were divided into 3 groups according to the genotypeswild homozygote group (CC group),mutation heterozygote (CT group) and mutation homozygote group (TT group).Patient-controlled intravenous analgesia was performed with sufentanil after operation.Visual analogue scale (VAS) scores at 24 and 48 h after operation,postoperative consumption of sufentanil,sleep quality score at 24 h after operation and state-trait anxiety score were recorded.Results Compared with CC group,VAS scores at 24 h after operation and postoperative consumption of sufentanil were significantly decreased in TT and CT groups,and the state-trait anxiety score was significantly decreased in TT group and increased in CT group (P＜0.05).Compared with TT group,VAS scores at 24 h after operation,postoperative consumption of sufentanil and the state-trait anxiety score were significantly increased in CT group (P＜0.05).There was no significant difference in sleep quality scores among the three groups (P＞0.05).Conclusion ABCB1 C3435T genetic polymorphism may be one of the mechanisms of the individual variation in the efficacy of postoperative analgesia.