Research advances in M. Tuberculosis polyketide synthase 13 inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1768-1773, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-825171
ABSTRACT
Polyketide synthase 13 (Pks13) performs a critical role in the final assembly step of mycolic acid synthesis in Mycobacterium tuberculosis. The inhibition of Pks13 can influence the biosynthesis of mycolic acid, which leads to Mycobacterium tuberculosis cell death. Researchers have discovered Pks13 inhibitors with five chemical scaffolds as antituberculosis agents. Herein, we summarize recent advances in the study of Pks13 inhibitors including the process of discovery, the mechanism of action and structure-activity relationships.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS