A meta-analysis on association between PM2.5 exposure and lung cancer based on cohort studies / 公共卫生与预防医学

ABSTRACT

Objectives To evaluate relationship between PM2.5 exposure and the risk of lung cancer. Methods Searched Chinese literatures with cohort studies from CNKI and Wanfang databases and English literatures with cohort studies from Pubmed, Embase, and Web of Science (from inception to April 2020),and the key words were “particulate matter”、“particle”、“PM2.5”、“lung cancer”、“lung carcinoma”、“lung tumor”、“lung tumour”、“lung neoplasm”、“lung adenocarcinoma”、“incidence”、“morbidity”. Used NOS to assess the quality of these studies , and used Stata 15.1 software to perform meta -analysis. Results A total of 6 articles were included.The fixed effect model was selected after heterogeneity test. (P>0.1, I2＜50%)The Meta-analysis showed that the risk of lung cancer may increase for per 10 μg/m3 of PM2.5 exposure (pooled RR= 1.07, 95%CI1.06-1.09). The results of sensitivity analysis showed that no significant changes in the combined effect were observed after excluding any study, indicating that the results of this meta-analysis were relatively stable. Conclusion The risk of lung cancer may increase with increased exposure to PM2.5 in air pollution.