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Serological Predictors for the Recurrence of Atrial Fibrillation After Electrical Cardioversion
Korean Circulation Journal ; : 185-190, 2010.
Artículo en Inglés | WPRIM | ID: wpr-8262
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Although electrical cardioversion (CV) is effective in restoring sinus rhythm (SR) in patients with atrial fibrillation (AF), AF frequently recurs in spite of antiarrhythmic medications. We investigated the predictors of failed CV and AF recurrence after successful CV. SUBJECTS AND

METHODS:

In 81 patients (MF=6318, 59.1+/-10.5 years old) with AF who underwent CV, clinical findings and pre-CV serologic markers were evaluated.

RESULTS:

During 13.1+/-10.6 months of follow-up, 8.6% (7/81) showed failed CV, 27.16% (22/81) showed early recurrence atrial fibrillation (ERAF; 2 weeks), and 32.1% (26/81) remained in SR and had no recurrence (NR). Plasma levels of transforming growth factor beta (TGF)-beta were significantly higher in patients with failed CV than in those with successful CV (p=0.0260). Patients in whom AF recurred were older (60.4+/-9.0 years old vs. 55.3+/-12.5 years old, p=0.0220), and had lower plasma levels of stromal cell derived factor (SDF)-1alpha (p=0.0105). However, there were no significant differences in these parameters between ERAF patients and LRAF patients.

CONCLUSION:

Post-CV recurrence commonly occurs in patients aged >60 years and who have low plasma levels of SDF-1alpha. High plasma levels of TGF-beta predict failure of electrical CV.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Recurrencia / Fibrilación Atrial / Cardioversión Eléctrica / Estudios de Seguimiento / Factor de Crecimiento Transformador beta / Células del Estroma / Quimiocina CXCL12 Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Anciano / Humanos Idioma: Inglés Revista: Korean Circulation Journal Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Recurrencia / Fibrilación Atrial / Cardioversión Eléctrica / Estudios de Seguimiento / Factor de Crecimiento Transformador beta / Células del Estroma / Quimiocina CXCL12 Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Anciano / Humanos Idioma: Inglés Revista: Korean Circulation Journal Año: 2010 Tipo del documento: Artículo