Methylmercury toxic mechanism related to protein degradation and chemokine transcription
Environmental Health and Preventive Medicine
;
: 30-30, 2020.
Artículo
en Inglés
| WPRIM
| ID: wpr-826302
ABSTRACT
Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enhance methylmercury toxicity. In addition, methylmercury exposure induces several immune-related chemokines, specifically in the brain, and may cause neurotoxicity. This summary highlights several molecular mechanisms of methylmercury-induced neurotoxicity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Saccharomyces cerevisiae
/
Quimiocinas
/
Toxicidad
/
Proteolisis
/
Metabolismo
/
Compuestos de Metilmercurio
/
Neurotoxinas
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Environmental Health and Preventive Medicine
Año:
2020
Tipo del documento:
Artículo
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