Advances in molecular mechanisms of meiotic arrest and luteinizing hormone-induced meiotic resumption in oocytes / 生理学报
Acta Physiologica Sinica
;
(6): 513-522, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-827035
ABSTRACT
Mammalian oocytes within Graafian follicles are arrested at prophase I of meiosis. C-type natriuretic peptide (NPPC), secreted by mural granulosa cells (MGCs), maintains oocyte meiotic arrest via binding to its cognate receptor natriuretic peptide receptor 2 (NPR2) and producing cyclic guanosine monophosphate (cGMP). NPR2 is most concentrated in the cumulus cells. In addition, cAMP, gap junction, inosine monophosphate dehydrogenase (IMPDH) and other important regulatory factors are also involved in meiotic arrest. Luteinizing hormone (LH) then rapidly decreases cGMP and induces oocyte meiotic resumption. In this paper, advances in the molecular mechanisms of meiotic arrest and LH-induced meiotic resumption were reviewed. This paper may provide new ideas for the prevention, diagnosis and treatment of related reproductive diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oocitos
/
Hormona Luteinizante
/
Péptido Natriurético Tipo-C
/
Células del Cúmulo
/
Genética
/
Meiosis
Límite:
Animales
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2020
Tipo del documento:
Artículo
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