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Implication of Early Lymphocyte Recovery after Allogeneic Hematopoietic Stem Cell Transplantation in Children with Leukemia
Yonsei Medical Journal ; : 62-70, 2013.
Artículo en Inglés | WPRIM | ID: wpr-82705
ABSTRACT

PURPOSE:

The repopulating lymphocytes after allogeneic hematopoietic stem cell transplantation have an important role not only on the prevention of serious infections in the early transplantation period, but also on the killing of residual leukemic cells by graft-versus-leukemia effect. The aim of this study was to analyze the impact of lymphocyte recovery after allogeneic stem cell transplantation in children with hematologic malignancies. MATERIALS AND

METHODS:

We evaluated 69 children transplanted for acute lymphoblastic leukemia (ALL) (n=34), acute myeloid leukemia (AML) (n=26), chronic leukemia (n=7) and juvenile myelomonocytic leukemia (n=2) between 1996 and 2008 at the Chonnam National University Hospital, Korea. The patients were grouped based on absolute lymphocyte counts (ALC) or =500/microL at D+21 and D+30 after transplant.

RESULTS:

Patients with a High ALC at D+21 and D+30 had a faster neutrophil and platelet engraftment. The High at D+30 group had a better 5 year overall survival (71% vs. 53%, p=0.043) and event-free survival (72% vs. 53%, p=0.065) than the Low at D+30 group. The incidence of grade II-IV acute and chronic graft-versus-host disease (GVHD), and relapse rate did not differ by the ALC counts. However, the Low at D+30 group had a significantly increased risk for transplant-related mortality (p=0.019). The univariate analysis showed that the factors associated with decreased survival were a Low ALC at D+30, patients with high risk ALL, and grade II-IV aGVHD in patients with ALL and AML.

CONCLUSION:

Early posttransplant serial lymphocyte measurement would be a simple but useful method for predicting transplant outcomes.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Recurrencia / Células Madre / Trasplante Homólogo / Plaquetas / Inducción de Remisión / Células Asesinas Naturales / Linfocitos / Leucemia / Estudios Retrospectivos Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adolescente / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Yonsei Medical Journal Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Recurrencia / Células Madre / Trasplante Homólogo / Plaquetas / Inducción de Remisión / Células Asesinas Naturales / Linfocitos / Leucemia / Estudios Retrospectivos Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Adolescente / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Yonsei Medical Journal Año: 2013 Tipo del documento: Artículo