Research Advances on Ex Vivo Expansion Strategy of Hematopoietic Stem Cells--Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1038-1043, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-827165
ABSTRACT
Abstract Hematopoietic stem cells (HSCs), as a kind of adult stem cell, is first used in clinical practice. It has been widely used in hematopoietic stem cell transplantation and has broad application prospects in the field of gene therapy. However, the shortage of HSC is still the main bottleneck restricting the clinical application of HSC transplantation, especially cord blood HSC transplantation. With the continuous improvement of the concept of HSC and the in-depth study of the molecular mechanism regulating HSC self-renewal and differentiation, it have been explored that a variety of strategies for ex vivo expansion of HSC, such as adding small molecule compounds in vitro culture system, simulating bone marrow microenvironment, regulating HSC metabolism and biomaterial-based amplification methods. In this review, recent advances in research of ex vivo expansion strategy of HSC are summarized and discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Médula Ósea
/
Células Madre Hematopoyéticas
/
Diferenciación Celular
/
Trasplante de Células Madre Hematopoyéticas
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2020
Tipo del documento:
Artículo
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