Clinical features and prognosis of core binding factor acute myeloid leukemia in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 739-743, 2020.
Article
en Zh
| WPRIM
| ID: wpr-828674
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To study the clinical features and prognosis of core binding factor acute myeloid leukemia (CBF-AML) in children.@*METHODS@#A retrospective analysis was performed from the chart review data of children who were newly diagnosed with CBF-AML in the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, from August 2009 to November 2015. According to the type of fusion gene, the children were divided into CBFB-MYH11 and AML1-ETO groups. Clinical features and prognosis were analyzed and compared between the two groups.@*RESULTS@#A total of 91 children with CBF-AML were enrolled in this study, among whom there were 74 (81%) in the AML1-ETO group and 17 (19%) in the CBFB-MYH11 group. Additional chromosomal abnormalities were observed in 38 children (42%), and deletion of sex chromosome was the most common abnormality and was observed in 28 children (31%). After the first course of induction treatment, the complete remission rate was 97% (88/91), the recurrence rate was 29% (26/91), the 5-year event-free survival (EFS) rate was 65%±6%, and the 5-year overall survival (OS) rate was 75%±5%. There were no significant differences between the AML1-ETO and CBFB-MYH11 groups in 5-year EFS rate (62%±7% vs 77%±11%, P>0.05) or 5-year OS rate (72%±6% vs 88%±9%, P>0.05).@*CONCLUSIONS@#AML1-ETO is the main type of fusion gene in children with CBF-AML, and deletion of sex chromosome is the most common type of additional chromosomal abnormalities. Children with CBF-AML often have a good prognosis, and the children with AML1-ETO have a similar prognosis to those with CBFB-MYH11.
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WPRIM
Asunto principal:
Pronóstico
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Leucemia Mieloide Aguda
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Proteínas de Fusión Oncogénica
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Estudios Retrospectivos
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Factores de Unión al Sitio Principal
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Subunidad alfa 2 del Factor de Unión al Sitio Principal
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Proteína 1 Compañera de Translocación de RUNX1
Tipo de estudio:
Observational_studies
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Prognostic_studies
Límite:
Child
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2020
Tipo del documento:
Article