Long-Term Aspirin Use and 5-Year Survival in Healthy Adults: A Population-Based Cohort Study in South Korea

ABSTRACT

Purpose@#We investigated whether long-term aspirin use is associated with 5-year all-cause mortality. @*Materials and Methods@#Participants were individuals aged ≥40 years who were registered in the 2010 sample cohort database of the National Health Insurance Service in South Korea. Aspirin users were divided into three groups continuous users (2006– 2010), previous users (2006–2009), and new users (2010). Individuals with a history of coronary artery disease and cerebrovascular disease were excluded. Five-year all-cause mortality was defined as mortality due to any cause from January 1, 2011 to December 31, 2015. Data were analyzed by multivariable Cox regression. @*Results@#In total, 424444 individuals were included. Five-year all-cause mortality was 9% lower in continuous aspirin users than in unexposed individuals [hazard ratio (HR) 0.91, 95% confidence interval (CI) 0.86–0.97; p=0.003]. Five-year all-cause mortality rates in the new aspirin users (HR 1.00, 95% CI 0.90–1.11; p=0.995) and previous aspirin users (HR 1.01, 95% CI 0.94–1.09; p=0.776) were not significantly different from that in unexposed individuals. In the 40–60-year age group, 5-year all-cause mortality in the continuous aspirin users was 24% lower (HR 0.76, 95% CI 0.64–0.90; p=0.002) than that in unexposed individuals. However, in the >60-year age group, there was no significant association between aspirin use and 5-year all-cause mortality (HR 0.96, 95% CI 0.90–1.02; p=0.199). @*Conclusion@#Long-term aspirin use is associated with reduced 5-year all-cause mortality in healthy adults, especially those aged <60 years.