FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 197-203, 2020.
Artículo
| WPRIM
| ID: wpr-834712
ABSTRACT
Objectives@#We compared the outcomes of two different doses of FK506 (tacrolimus) for immunosuppression in submandibular salivary gland (SMG) allotransplantation. @*Materials and Methods@#Three SMG allotransplantation groups were established (n=6 per group) as follows allograft rejection control (Allo-Ctrl), low dose (0.08 mg/kg) of FK506 (FK506-L), and high dose (0.16 mg/kg) of FK506 (FK506-H). Allograft survival and rejection were assessed by clinical observation, interleukin-2 levels as determined by enzyme-linked immunosorbent assay, blood sampling for complete blood count (CBC), and histological evaluation. @*Results@#Body weight and anorexia were higher in the FK506-H group but without a significant difference compared with the FK506-L population. CBC revealed a non-significantly reduced number of changes in the FK506-L group. Four glands in the FK506-H group and two glands in the FK506- L group were viable and functioning post-transplantation. @*Conclusion@#The survival rate of allotransplanted glands was higher in conjunction with the high dose of 0.16 mg/kg of FK506, with no major difference in the side-effect profile when compared with the low dose of 0.08 mg/kg short-term outcomes.
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Índice:
WPRIM (Pacífico Occidental)
Revista:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Año:
2020
Tipo del documento:
Artículo
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