Research progress of GWAS in hyperuricemia / 公共卫生与预防医学
Journal of Public Health and Preventive Medicine
;
(6): 109-113, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-837495
ABSTRACT
Hyperuricemia is a chronic disease caused by the imbalance of uric acid synthesis and excretion, which is influenced by both environmental and genetic factors. The results of genome-wide association analysis related to hyperuricemia in different regions during the past decade have shown that genes related to hyperuricemia may be region- specific. This article summarizes the genes detected by GWAS, and describes some of the involved molecular mechanisms. The genes related to hyperuricemia shared by people in Europe, Asia, Africa and South America, and genes related to hyperuricemia unique to Asian populations are reviewed in this article. In addition, some of the genes’ functions are discussed to enhance the understanding of the pathogenesis of hyperuricemia.
Buscar en Google
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Public Health and Preventive Medicine
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS