A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots
Natural Product Sciences
; : 213-216, 2017.
Article
en En
| WPRIM
| ID: wpr-83903
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WPRO
ABSTRACT
Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2), pimpinellin (3), and (3S, 4R)-3, 4-epoxypimpinellin (4). All the isolated compounds 1, 2, 3, and 4 showed moderate inhibition activities against acetylcholinesterase with the IC₅₀ values of 10.2, 18.1, 21.5 and 22.9 µM, respectively. (3S, 4R)-3, 4-Epoxypimpinellin (4) was newly isolated from the plant source.
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Asunto principal:
Plantas
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Acetilcolinesterasa
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Inhibidores de la Colinesterasa
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Cumarinas
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Heracleum
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Métodos
Idioma:
En
Revista:
Natural Product Sciences
Año:
2017
Tipo del documento:
Article