Expression of SALL4, Bmi-l and β-catenin in esophageal squamous cell carcinoma and the related clinical significance / 第二军医大学学报

ABSTRACT

Objective To investigate the expression of SALL4, Bmi-1 and β-catenin in esophageal squamous cell carcinoma (ESCC) and the related clinical implications. Methods Immunohistochemical staining was used to detect the expression of SALL4, Bmi-1 and β-catenin in 70 normal esophageal mucosa specimens, 70 dysplasia mucosa specimens and 123 ESCC specimens; and the relationship of their expression with the clinicopathological characteristics of ESCC was analyzed. Results The positive rates of SALL4, Bmi-1 and the aberrant rate of β-catenin expression gradually increased in order in normal esophageal mucosa, dysplasia mucosa andESCC groups. The positive rates of SALL4, Bmi-1 and the aberrant rate of β-catenin expression in the dysplasia mucosa and ESCC groups were significantly higher than those in normal esophagealmucosa group (P0. 05). In the dysplasia mucosa group, the positive rate of Bmi-1 increased along with the degree of dysplasia (P<0. 01). In the ESCC cases, the positive rate of Bmi-1 and aberrant rate of β-catenin were corelated with depth of invasion, degree of differentiation and lymph node metastasis of ESCC (P<0. 05), and positive rate of SALL4 was correlated with the clinical staging (P<0. 05) and lymph node metastasis of ESCC (P<0. 01). The expression of SALL4, Bmi-1 and β-catenin in the 123 cases of ESCC were positively correlated with each other (SALL4 and Bmi-1 r = 0. 373, P<0. 01; SALL4 and p-catenin r=0. 214, P<0. 05; Bmi-1 and p- catenin r=0. 204, P<0. 05). Conclusion SALL4, Bmi-1 and β-catenin might be involved in the development, progression, invasion and metastasis of ESCC; and the three of them might interact through corresponding signal pathways.