Charlson'S weighted index of comorbidities in assessing prognosis of septic patients / 第二军医大学学报

ABSTRACT

Objective To investigate the value of Charlson's weighted index of comorbidities (WIC) in predicting the prognosis of patientswith sepsis. Methods The clinical data of 234 septic patients in the last three years were retrospectively analyzed. The scores of WIC and acute physiology and chronic health evaluation II (APACHE II) were calculated. The patients were divided into two groups according to death or survival outcome 28 days later, and the value of WIC score in predicting prognosis was analyzed. Results It was found that 77 (32. 9%) of the 234 patients died. Increasing WIC score was associated with increased mortality. Multiple logistic regression analysis revealed that WIC was a risk factor of prognosis of septic patients (QR = 1. 434, 95% CI1. 097-1. 875, P = 0. 008). The areas under the ROC curves in predicting the mortality of the septic patients were 0. 670 (0.591-0.748) for the WIC score, 0.770 (0.703-0.837) for APACHE II score and0. 821 (0. 757-0.885) for the combination of both. Conclusion WIC score can satisfactorily predict the influence of underlying diseases on the prognosis of septic patients.