Chronic kidney disease-mineral and bone disorder and energy metabolism / 第二军医大学学报

ABSTRACT

The damage of chronic kidney disease-mineral and bone disorder (CKD-MBD) has drawn increasing attention in recent years. In addition to traditional pathogenic factors, energy regulatory factors such as leptin, insulin, and adiponectin also participate in the development and progression of CKD-MBD. Hyperleptinaemia can directly or indirectly affect bone formation. CKD patientswith diabetes have injured osteoblast function and are liable to have low dynamic osteopathy with low parathyroid hormone (PTH). Adiponectin is increased in CKD patients, which can be used as a marker forseverity of osteopathy. More basic and clinical researches are needed to elucidate the mutual influence between CKD-MBD and energy metabolism. The interventions targeting molecular mechanisms may bring new treatments to CKD-MBD. This paper reviewed the mutual influence of CKD-MBD and energy metabolism.