Gastrointestinal symptoms in patients with peritoneal dialysis: Multivariate analysis of correlated factors / 第二军医大学学报

ABSTRACT

Objective To evaluate the gastrointestinal (GI) symptoms of peritoneal dialysis (PD) patients and to explore the related factors contributing to GI symptoms. Methods Gastrointestinal Symptom Rating Scale (GSRS) was used for subjective evaluation of GI symptoms in PD patients. The information of patients was obtained by inquiring patients or review of medical records. Multiple regression analysis with stepwise backward variable selection was used to identify factors correlated with GSRS scores. Results The prevalence rate of gastrointestinal symptoms was 61.6% in the PD patients. The prevalence rates of eating dysfunction, reflux and indigestion were 43.8%, 32.1%, and 32.1%, respectively. We found that age (B=0.006, P=0.027), history of corticosteroid therapy (B=0.51,P<0.001) and daily tablet number (B=0.009, P=0.005) were positively correlated to GSRS score; and residual renal Kt/V (B=-0.27, P=0.001) was negatively correlated with GSRS score. Moreover, females seemed to have more GI symptoms than males (B=-0.15, P=0.033). The above five factors mentioned above could predict 36% of the GSRS score. Conclusion Eating dysfunction, reflux and indigestion are the most common disorders in PD patients. Old age, female sex, more daily tablet number and corticosteroid history are correlated with more severe GI symptoms, while residual renal function might be a preventing factor of GI symptom.