Effect of left superior pulmonary vein fat pad on atrial fibrillation in dogs / 第二军医大学学报

ABSTRACT

Objective Toexplore the effect of ablation of left superior pulmonary vein fat pad (LSPV-FP) on atrial fibrillation(AF). Methods Twelve healthy adult mongrel dogs were anesthetized and ventilated; both cervical vagosympathetic trunks were exposed for stimulation. Thoracotomies at the 4th intercostal space of left and right chest were performed to expose the LSPV-FP. The effective refractory period(ERP)/ERP-dispersion (dERP) of atrium and LSPV, AF inducibility, and the ventricular rate of AF were measured in the following statuses baseline, vagosympathetic trunk stimulation(VTS), LSPV-FP ablation, and VTS post LSPV-FP ablation. Results At baseline status, stimulation of the left or right vagosympathetic trunks significantly shortened the ERP of atrial ([84. 44±29.50] ms vs [129. 7± 15. 83] ms, [85. 42±26. 11] ms vs [129. 7± 15. 83] ms, P<0. 05), increased the dERP of atrial ([71. 67 ± 14. 03] ms vs [34. 17 ± 18. 32] ms, [57. 5 ± 24. 17] ms vs [34. 17 ± 18.32] ms, P<0. 05), the difference of ERP between proximal and distal of LSPV(P<0. 05), AF inducibility ([5. 33± 231] times vs [0. 75±0. 96] times, [4. 67± 1. 155] times vs [0. 75±0. 96] times, P<0. 05), and deceased the ventricular rate of AF([143. 6±22. 42] beats/min vs [226. 3±28. 50] beats/min, [146. 4±30. 72] times/min vs [226. 3±28. 50] times/ min, P<0. 05). LSPV-FP ablation significantly attenuated all the above electrophysiological changes induced by left VTS(P< 0. 05), but showed no effects on those induced by right VTS. Conclusion Left vagosympathetic trunk plays an important role in the development and maintenance of AF partially through LSPV-FP.