Effects of Sandalwood on pharmacokinetics of gallic acid and protocatechuic acid in Choerospondiatis fruit / 第二军医大学学报

ABSTRACT

Objective: To establish a HPLC method for in vivo determination of gallic acid (GA) and protocatechuic acid (PA) in rat plasma, and to study the effect of Sandalwood on the pharmacokinetics of GA and PA. Methods: SD rats were given the water extracts of Choerospondiatis fruit or Choerospondiatis fruit and Sandalwood. The pharmacokinetic parameters of GA and PA were calculated by DAS2. 0 software at different time points after an oral ration of the above extracts. Results: The pharmacokinetic parameters after oral administration of Choerospondiatis fruit extract were as follows GA Cmax (0.112±0.008) mg·L-1, CL/F (0.132±0.016) L·min-1·kg-1, t1/2β (69.3±0) min, Tmax (45.0±0) min; PA Cmax (0.550±0.028) mg·L-1, Tmax (52.0±0) min, t1/2β, (60.7±1.1) min; CL/F (0.078±0.011) L·min-1·kg-1. The pharmacokinetic parameters after oral ration of Choerospondiatis fruit-Sandalwood extract were as follows GA Cmax (0.187±0.010) mg·L-1, CL/F (0.094±0.017) L·min-1·kg-1, t1/2β (69.3±3.3) min, Tmax (30.0±0) min; PA Cmax (1.080±0.066) mg·L-1, Tmax (45.0±0) min, t1/2β (69.3±0.2) min, CL/F (0.011±0.001) L·min-1·kg-1. Conclusion: Oral ration of Choerospondiatis fruit-Sandalwood extract results in earlier plasma peaks of PA and GA, lower clearance rate, and longer half life, indicating Sandalwood can promote the absorption of phenolic compounds in Choerospondiatis fruit.