Decreased XAB2 expression and gastric cancer / 第二军医大学学报

ABSTRACT

Objective: To investigate the changes of XAB2 mRNA and protein expression in gastric cancer tissues, so as to discuss its possible relationship with the development of gastric cancer. Methods: XAB2 mRNA expression in 34 gastric cancer tissues and the matched adjacent normal tissues was examined by real-time RT-PCR. Meanwhile, tissue biochip and immunohistochemistry were employed to examine XAB2 protein expression in gastric cancer tissues, matched adjacent normal tissues, and gastritis tissues. The expression of XAB2 in different tissues and its clinical significance was analyzed. Results: XAB2 mRNA expression in the gastric cancer tissues was significantly lower than that in corresponding adjacent normal tissues (P 0. 05). Conclusion: The lower XAB2 expression might be closely associated with the development and progression of gastric cancer, and further studying may benefit the diagnosis and therapy of gastric carcinoma patients.