Modulation mechanism of PKC upon inwardly rectifying potassium channels / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 956-960, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-840522
ABSTRACT
Inwardly rectifying potassium (Kir) channels are widely distributed in many tissues and play important roles in physiological processes such as maintaining K+ homeostasis, regulating cell excitability and insulin secretion. The activity of Kir channels is regulated by a number of modulators,such as K+, Mg2+, pH, ATP, GPCR, PIP2, PKA, PKC, AA (arachidonic acid), etc. Study of the regulating mechanisms of Kir channel is a key step in understanding the physiology and physiopathology of these channels. Because many extra molecular signals regulate Kir channels via PKC pathway, much effort has been made over the past decade to understand role of PKC in regulating Kir channels. This paper summarizes the molecular basis of PKC modulation of Kir channels and the recent progression on the area.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS