Analysis of factors affecting intrahepatic infection after percutaneous radiofrequency ablation for liver cancers / 第二军医大学学报

ABSTRACT

Objective: To investigate the factors affecting the intrahepatic infection after percutaneous radiofrequency ablation (PRFA) for liver cancers. Methods: The clinical data of 1 567 patients with intrahepatic infection after PRFA for liver cancers (from Dec. 1999 to Oct. 2007) were retrospectively summarized. Logistic regression method was used to analyze the possible affecting factors. Results: Twenty-eight person-times of intrahepatic infection occurred in 1 635 patients who received a total of 2 035 times of PRFA, with the infecting rate being 1.38%. The intrahepatic infection-related mortality was 0.13% (2/1 567). Univariate analysis indicated that the intrahepatic infection was significantly correlated with metastatic liver cancer, pattern of past abdominal operation, tumor location, tumor size and tumor numbers (P<0.05). Multivariate analysis showed that the types of liver cancer, tumor number, tumor location and pattern of past abdominal operation were independent risk factors for intrahepatic infection after PRFA for liver cancers(r=3.647, P=0.004; r=1.155, P=0.042; r=1.701, P=0.019; r=2.213, P=0.010, respectively). Conclusion: Our findings suggested that patients with metastatic liver cancer(especially for the patients who have received gastroenterostomy or cholangioenterostomy), multi-liver cancer, and cancers locating near the cavity organs are liable to intrahepatic infection after PRFA.